5 years of PPI use resulted in 162% increased incident of hip fractures
7 years of PPI use resulted in 192% increased incident of osteoporosis related fractures and a 455% incident of hip fractures.
Full report in the CMAJ, August 2008. http://www.cmaj.ca/cgi/content/full/179/4/319
2006 study with similar conclusion published in the JAMA:
http://jama.ama-assn.org/cgi/content/abstract/296/24/2947?lookupType=volpage&vol=296&fp=2947&view=short