Heartburn drugs harm effectiveness of Plavix-Second study

CHICAGO, Nov 11, 2008 - Popular heartburn drugs increase the risk of heart attack or stroke when taken together with the widely prescribed blood thinner Plavix, according to a study released on Tuesday.

Patients taking proton pump inhibitors such as Nexium or Prilosec had a 50 percent higher risk of a major cardiovascular event when also taking clopidogrel, the active ingredient in Bristol-Myers Squibb Co's blood clot preventer Plavix, according to the study by pharmacy benefit manager Medco Health Solutions Inc.  Click below to read more

http://www.reuters.com/article/rbssHealthcareNews/idUSN1142966320081111

FDA Early communication on safety concerns 1/26/2009

http://www.fda.gov/cder/drug/early_comm/clopidogrel_bisulfate.htm

Prilosec May Blunt Plavix Benefit

PPI Acid-Reducing Drugs May Block Anticlot Medicine Needed by Stent Patients By Daniel J. DeNoon
WebMD Health News Reviewed by Louise Chang, MD

Jan 14, 2008 -- Prilosec and other PPI acid-reducing drugs prevent gastric bleeding in stent patients on Plavix, but the drugs may block Plavix's lifesaving anticlot action.     Click below to read more.... http://www.webmd.com/heart-disease/news/20080114/prilosec-may-blunt-plavix-benefit

Abstract of the randomized, double-blind study http://content.onlinejacc.org/cgi/content/abstract/51/3/256?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=Gilard&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT